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@#Cataract is a kind of eye disease that causes lens metabolic disorder and protein degeneration and turbidity due to various reasons. Congenital cataract is especially serious. It is a common eye disease that affects the visual development of infants. It can inhibit the development of visual pathway and cause permanent blindness. About one-third of the cases are genetically related, of which autosomal dominant inheritance is the most common genetic mode. It's occurrence and development may be related to genes involved in lens development. Up to now, hundreds of mutation sites in more than 40 genes have been found to be associated with congenital cataract. This article will review the genetic research progress of congenital cataract.
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Objective:To analyze the risk factors of positive surgical margin and residual lesions after cone resection of high-grade intraepithelial neoplasia, and to guide clinical work and follow-up.Methods:The clinical data of 180 patients with cervical epithelial neoplasia of grade Ⅱ and Ⅲ who underwent cervical conization in the People's Hospital of Inner Mongolia Autonomous Region from November 2013 to November 2018 were retrospectively analyzed.The risk factors associated with residual margin and reoperation (including re-cone and hysterectomy) after conization were performed by single factor and multivariate regression analysis.Results:The incidence of positive resection margins after conization was 31.67%(57/180), which of the residual margin of re-surgery was 36.84%(21/57). Menopause, contact bleeding, cervical cancer(in situ carcinoma, microinvasive carcinoma) were positive risk factors for conical cutting margin ( OR=2.342, 2.428, 8.949). Contact bleeding, cervical cancer(in situ carcinoma, microinvasive carcinoma) were risk factors for residual resection of the surgical margin after conization ( OR=5.370, 10.992). Conclusion:Contact bleeding, cervical carcinoma in situ, microinvasive carcinoma are closely related to cervical margin and lesion residual.Among them, menopause is also positively related to margin, which is a risk factor affecting cervical cone cutting margin and residual reoperation.It should be highly valued in clinical.
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<p><b>OBJECTIVE</b>To investigate the value of ischemic myocardial viability assessment using interleaved T1-T2* magnetic resonance imaging.</p><p><b>METHODS</b>The left anterior descending coronary arteries (LAD) were occluded for 2 hours, followed by 1-hour reperfusion in 7 pigs. The hearts were then removed and perfused with a mixture of pig blood and crystalloid solution in 1:1 ratio. T1 relaxation times of the myocardium were measured with a TurboFLASH inversion-recovery sequence. The contrast agent, Gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) was then injected as a bolus into the aortic perfusion line (0.05 mmol/kg body wt). The first pass of the contrast agent through the heart was followed using the interleaved T1-T2* imaging sequence. Once the concentration of Gd-DTPA was in an equilibrium state, T1 relaxation times were measured again.</p><p><b>RESULTS</b>The percentage recovery of T2* intensity (PRT2*) at the maximum T1 intensity measured during the first pass of the contrast agent with the interleaved T1-T2* imaging was statistically different in normal myocardium (37 +/- 11)%, infarct rim (90 +/- 15)% and infarct core (100 +/- 5)%, F = 66.585, P = 0.000. Moreover, the infarcted regions shown on PR(T2)* maps matched well with the infarcted myocardium measured by TTC staining. The median of T(1) relaxation time in normal region, infarct rim and infarct core was 531 ms, 541 ms and 1298 ms, respectively (H = 6.284, P = 0.043). However, normal region could not be differentiated from infarct rim with T1 relaxation times (q = 0.082, P = 0.775).</p><p><b>CONCLUSION</b>Infarcted myocardium and ischemic myocardial viability can be correctly identified and evaluated by the interleaved T1-T2* magnetic resonance imaging in this model.</p>